When Henry Ford made cheap, reliable cars people said, 'Nah, what's wrong with a horse?' That was a huge bet he made, and it worked.
When something is important enough, you do it even if the odds are not in your favor.
Some people don't like change, but you need to embrace change if the alternative is disaster.
I think that's the single best piece of advice: constantly think about how you could be doing things better and questioning yourself.
I think life on Earth must be about more than just solving problems... It's got to be something inspiring, even if it is vicarious.