Of course there are depressing periods when nothing appears to be happening. But whenever anything was happening, and even when nothing was happening, it was fun just to do phage experiments.
That's the nice thing about doing research. Whatever you do is novel, so you always have this sense of novelty, even if you are only using a new gadget.
Different viral species contain nucleic acids that differ not only in length and nucleotide sequence but in many unexpected ways as well.
Joseph Mandell and I began by attempting to make chromatography of DNA work.
Physical studies of DNA had, of course, been under way for some years before analysis of virus particles began.